The Effect of Glucocorticoid on Gluconeogenesis in Rats with Liver Damage.

It has been noted that steroid diabetes occurs more frequently in patients with liver disease and patients with blood disease than in those without such diseases during treatment of glucocorticoid (Yamagata and Goto, 1963). We have also reported that glucosuria during administration of glucocorticoids was often noted in patients with liver disease, especially in the acute stage of liver damage (Oji, 1963b; Oji and Wada, 1963). It is known that the diabetes produced by glucocorticoids in characterized by a marked increase in gluconeogenesis. However, a particular effect on gluconeogenesis in the demaged liver has not been recognized. Therefore, in the present study, the influence of cortisone upon gluconeogenesis was investigated with DL-alanine-1-C14 in rat with acute or chronic carbon tetrachloride poisoning.